MULTIOMICS ANALYSIS SERVICES
Your partner for integrative biomarker analysis & personalized diagnostic solutions
AIT Molecular Diagnostics – your one-stop shop for multi-omics analysis. From assay development to high-throughput processing, bioinformatics, and validation of results – we provide end-to-end solutions from your biospecimens, fully tailored to your project needs
Multi-Omics Services Overview
The following table provides a structured overview of our core areas and analytical services:
Omics Layer
Analytical Services
Genomics
• Genotyping, mutation detection…
• Illumina-arrays & NGS
• NGS (Illumina, PacBio, Oxford Nanopore)
• tissue derived (e.g. FFPE) and liquid biopsy (cfDNA)
Epigenomics
• DNA-Methylation
• Illumina-arrays & NGS
• Biological Age
Transcriptomics
- RNA-Seq / tissue and bodyfluid derived
- miRNA / exosomal miRNA
- ncRNA
- mRNA
Proteomics & Immunomics
- Olink Proteomics (48-5400 targets)
- Antibody profiling with
- Protein- und Peptid-arrays
- Luminex Bead Arrays
- PhIP-NGS
Metagenomics
- Microbiome
- 16S/18S /ITS
- Resistances
- Metagenome
Metabolomics
- with our associated partners
- MassSpec based
- NMR based
Our Multi-Omics Services and beyond
We provide a comprehensive multi-omics portfolio and support every step of your project, including experimental design, pre-analytics, sample handling (controlled processing, aliquoting, and tracking), as well as bioinformatics. In addition, we offer confirmation and validation studies with targeted assays – from assay setup to efficient data analysis – to maximize the output from your samples.
Unlock the full potential of your samples with our end-to-end multi-omics solutions. We support you from experimental design and sample logistics to advanced bioinformatics — ensuring your study is efficient, reproducible, and impactful.
Need validation? We offer custom assay development, confirmation studies, and expert advice to unleash the full potential from your data.
Pre-analytics
- Sample preparation (e.g., DNA/RNA isolation)
- Quantification and quality control
Genomics
- DNA genotyping and mutation-detection
- Illumina Global Screening Array v3/v4 – we accept any sample numbers
- All other Illumina arrays can be provided.
- Next Generation Sequencing (NGS)
- Targeted and customized assays for detection of low frequent mutations / alleles
- Whole Genome Sequencing (WGS)
- Available platforms: Illumina, PacBio, Oxford Nanopore Technology
Epigenomics
- Whole genome DNA Methylation Analysis with various technologies including bioinformatics
- EPIC v2 Array (~930.000 CpG sites)
- TWIST Human Methylome Panel (3.98M CpG sites)
- Nanopore Methylation Sequencing
- Customized and targeted DNA methylation analysis
- NGS-based DNA-methylation-panels
- Amplification based (10-1000 plex)
- Hybridization capture bead based customized approaches (10-100.000 plex)
- Detection of e.g. 0.1% tumor DNA in background DNA
- Customized MSRE-qPCR based panels (48-96 plex)
- AIT’s standard targeted 480 plex MSRE-qPCR-panel (target list download)
- NGS-based DNA-methylation-panels
Transcriptomics
- Gene expression analyses (mRNA, miRNA, ncRNA)
- RNA sequencing (RNA-Seq) and targeted panels
- Transcriptomics of bodily fluid samples (liquid biopsy)
- Exosomal miRNA (200-500µl serum or plasma)
Proteomics & Immunomics
- Olink® Explore and Olink Targeted Proteomics
- OLINK® PEA technology, supporting projects from study design to data analysis
- Broad capabilities – targeted proteomics and assay formats up to 5,400 biomarkers
- Key advantages – low sample use, high specificity, and wide dynamic range
- Antibody profiling
- Protein and peptide arrays (microarray- & Luminex® bead array- based)
- Array and NGS based proteome-wide formats using / providing AIT, CDI, KREX, InfinityBio as well as customized formats
- Antibody reactivity against pathogens (e.g. AIT’s 260x human pathogen array (serum antibody profiling associated with bacterial infections), viruses, allergens (e.g. VirScanTM, VirsigthTM, AllersigthTM…)
- 10-50µl Serum oder Plasma as startmaterial, request for other sample types
Metagenomics
- Complete metagenomic analyses (tissue, cfDNA)
- Microbiome characterization (e.g., gut, saliva)
- 16S/18S /ITS – analytics
- Antibiotics resistance detection
Bioinformatics & Data Integration
Our specialized analysis pipelines combine molecular data with clinical trial parameters:
- Assay Design & Validation
- Biostatistics & Visualization
- Disease Modelling & Network Analysis
- Multi-Modal e-Data Integration
- Customized Software Solutions
Sample types tissue (nativ und FFPE)
Blood, cell cultures and supernatants thereof, liquid biopsy, liquor, urine, saliva, etc.
Typical Fields of Application
- Early detection & prognosis (e.g. cancer, infections, autoimmunity)
- Therapy monitoring & companion diagnostics
- Development of non-invasive diagnostic tests (liquid biopsy )
- Project-accompanying omics analyses
- Contract research & study support
Our Services for you
- Tailor-made service packages for industry & research
- Validation projects, prototype development, software design under GLP-conditions
- Support at clinical study planning & implementation
- Advice to feasibility & study architecture
CONTENT
PD DR ANDREAS WEINHÄUSEL
